Formation and characterization of chitosan-polylacticacid-polyethylene glycol-gelatin nanoparticles: a novel biosystem for controlled drug delivery.

نویسندگان

  • M Rajan
  • V Raj
چکیده

Chitosan (CS)-polylacticacid (PLA)-polyethylene glycol (PEG)-gelatin (G) nanoparticles, a novel drug vehicle for the controlled release of an antitubercluosis drug, rifampicin (RIF) was developed and its chemical and biochemical activities were studied by various standard methods. The designed carriers CS, PEG and G nanoparticles were prepared by emulsion solvent evaporation technique, and then used for entrapping RIF. Linking was confirmed by FTIR spectroscopy. The surface morphology of the nanoparticles was studied using scanning electron microscope and polarizing microscope. The influence of process variables, on particle size, zeta potential and matrix entrapment of RIF was studied. The encapsulation and loading capacity were evaluated, and an in vitro release of RIF was assessed using the dialysis method. The effect of nanoencapsulation of RIF on the antibacterial activity of RIF against Mycobacterium strains was evaluated. The preliminary results clearly suggested that the cross linked CS-PLA-PEG-G matrix may be a potential polymeric carrier for controlled delivery of RIF.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Dissertation zur Erlangung des Doktorgrades der Fakultt fr Chemie und Pharmazie der Ludwig-Maximilians-Universitt Mnchen - NANOPARTICLES FOR RNA INTERFERENCE - NOVEL PRECLINICAL FORMULATIONS FOR SIRNA MEDIATED GENE THERAPY

1 1 GENERAL INTRODUCTION 3 1.1 Endothelial related diseases 3 1.2 siRNA and the principle of RNA interference 8 1.3 RNA interference in research and therapy 13 1.4 Viral and non-viral gene delivery 14 1.5 Nanoparticles: definitions, history and current state of knowledge 16 1.6 Gelatin based nanoparticles as colloidal drug delivery vectors 18 1.7 Body distribution of nanoparticles 19 1.8 Nanopa...

متن کامل

Preparation, characterization and stability investigation of chitosan nanoparticles loaded with the Echis carinatus snake venom as a novel delivery system

The chitosan nanoparticles used widely as a drug delivery systems recently. In the present study the Echis carinataus snake venom loaded chitosan nanoparticles were prepared based on ionic gelation of tripolyphosphate and chitosan. The nanoparticles physicochemical characteristics, stability and biological activity of encapsulated venom were studied. The particles were spherical in shape and th...

متن کامل

Design and Characterization of Mesalamine Loaded Nanoparticles for Controlled Delivery System

Objective(s): Nanoparticles (NPs) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. The main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. Methods: In this study, me...

متن کامل

Controlled Antibiotic Delivery by Gelatin Nanospheres: Optimization, Characterization and Antibacterial Evaluation

The present work focuses on preparation and characterization of erythromycin loaded gelatin nanoparticles through nanoprecipitation method. The procedure consists of the addition of the aqueous gelatin solution to the non-solvent phase containing Lutherol F127. Three different measures of cross-linker and polymer concentration were also examined, and the optimum concentration was found. The mor...

متن کامل

Evaluation of protein corona formation and anticancer efficiency of curcumin-loaded zwitterionic silica nanoparticles

Objective(s): Study and development of antifouling nanosystem for conjugation of drugs were attracting great attention in recent years. The present study aimed to develop novel curcumin-loaded silica nanoparticles containing zwitterionic coating as an antifouling system to provide protein corona free nanoformulations for curcumin. Materials and Methods: Silica nanoparticles were prepared ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Carbohydrate polymers

دوره 98 1  شماره 

صفحات  -

تاریخ انتشار 2013